Antidepressivum hilft gegen Corona (Corona)

Annika, Luzern, Samstag, 24.10.2020, 03:17 (vor 1277 Tagen) @ Donutking

Trotz Nebenwirkungen haben "diese Medikamente" (z.B. SSRI) als Anti-Depressiva eingesetzt ihre Berechtigung. Entscheidend ist eine engmaschige Begleitung bei der medikamentösen Einstellung, denn ja, je nach Person können Nebenwirkungen auftreten, da eben nicht jedes Medikament für jede Person geeignet ist.

Nein, haben Sie nicht. Meiner Meinung nach gibt es überhaupt keine physiologische Basis für den Einsatz von SSRIs oder ähnlichen Serotoninagonisten bei Leuten mit Depressionen, oder generell für irgendwen. Wir wissen mittlerweile (und wussten es auch damals), dass Serotonin eine pathologische Rolle in vielen degenerativen Krankheiten spielt und der unbedachte Einsatz jedes Medikaments, das die Wirkung von Serotonin steigert, ist grob fahrlässig, um es milde auszudrücken.

Von einem Zusammenhang von erhöhtem Serotonin-Spiegel und degenerativen Erkrankungen wusste ich bislang nichts. Danke für den Hinweis. Werde ich mich mal näher mit beschäftigen. :-)

Mein Stand war bislang nur, dass bei Menschen mit verschiedenen psychischen Erkrankungen ein verringerter Serotonin-Spiegel beobachtet werden kann.

My pleasure. Dass Depressionen im Zusammenhang mit verringerten Serotoninspiegeln stehen ist schlicht falsch und die Vermarktung und Verschreibung von Serotoninagonisten an Millionen von Menschen eines der größten medizinischen Skandale der letzten 100 Jahre. Es gab nie belastbare Beweise für diese Hypothese und trotz der Forschung der letzen Jahrzehnte, die zeigt, wie gefährlich Serotonin ist, werden SSRIs immer noch wie Gummibärchen verkauft und von Ärzten bedenkenlos verschrieben.

Unten sind ein paar gute Stellen, wenn man anfangen möchte, sich in die Materie einzulesen. Serotonin trägt zu vielen Krankheiten bei, vor allem solchen, die einem gestörten Stoffwechsel folgen, i.e. Übergewicht, Diabetes, etc. Aber auch Autismus, Fibrose und verschiede Tumorarten. Pfizer z.B. gibt seit mehreren Jahren riesige Summen für die Entwicklung neuer Serotoninantagonisten aus und hat viele vielversprechende Studien vorgelegt.

Science behind commonly used anti-depressants appears to be backwards, researchers say

Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response

"...The low-serotonin theory is the basis for commonly prescribed anti-depressant medications called selective serotonin re-uptake inhibitors, or SSRIs, which keep the neurotransmitter's levels high by blocking its re-absorption into the cells that release it. Those serotonin-boosting medications actually make it harder for patients to recover, especially in the short term, says lead author Paul Andrews, an assistant professor of Psychology, Neuroscience & Behaviour at McMaster...When depressed patients on SSRI medication do show improvement, it appears that their brains are actually overcoming the effects of anti-depressant medications, rather than being assisted directly by them. Instead of helping, the medications appear to be interfering with the brain's own mechanisms of recovery."

"...The best available evidence appears to show that there is more serotonin being released and used during depressive episodes, not less, the authors say. The paper suggests that serotonin helps the brain adapt to depression by re-allocating its resources, giving more to conscious thought and less to areas such as growth, development, reproduction, immune function, and the stress response."

What has serotonin to do wtih depression

"Indeed, dogged by unreliable clinical biochemical findings and the difficulty of relating changes in serotonin activity to mood state, the serotonin hypothesis eventually achieved “conspiracy theory” status, whose avowed purpose was to enable industry to market selective serotonin reuptake inhibitors (SSRIs) to a gullible public (3)."

Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature

"In 1998, at the dawn of consumer advertising of SSRIs, Professor Emeritus of Neuroscience Elliot Valenstein summarized the scientific data by concluding, “What physicians and the public are reading about mental illness is by no means a neutral reflection of all the information that is available” [50]. The current state of affairs has only confirmed the veracity of this conclusion. The incongruence between the scientific literature and the claims made in FDA-regulated SSRI advertisements is remarkable, and possibly unparalleled."

Serotonin promotes obesity and diabetes

"...In a new development in gastrointestinal research, researchers from Flinders University, SAHMRI and the University of Adelaide have found more evidence that elevated concentrations of serotonin, the crucial neurotransmitter that chemically transmits messages to nerve cells in the body, is also linked to obesity. Only recently have researchers understood that this "gut serotonin" is actually bad for our metabolism, as it increases blood glucose and fat mass, thus endangering us of developing diabetes and obesity. The new research demonstrates for the first time in humans that this gut serotonin is doubled in obese individuals. This new insight now paves the way to try and find potential new treatments for obesity by focusing on the cells in our gut that produce this hormone. The South Australian researchers were part of a large international research team including University of Adelaide experts that found human obesity is characterised by an increased capacity to produce and release serotonin in the gut."

"...We know from a raft of recent high profile publications that gut-derived serotonin causes diabetes and obesity, but we didn't know if this was relevant to such disorders in humans. Our findings are the first work implicating serotonin as a driver of worsening obesity in humans," says Professor Keating. "Having established this, we can now focus on understanding why this happens, so we can develop methods to reduce circulating serotonin levels. These sorts of therapeutic outcomes are exactly why Pfizer decided to partner with us in this research area over the past four years." University of Adelaide Senior Research Fellow, Associate Professor Richard Young, says these findings also indicate that obese humans secrete excess serotonin from the upper gut at rest, as well as during a meal. "This has revealed new ways that we may be able to control the release of serotonin from within the gut, and in turn, further improve the outlook for people living with obesity", says senior co-author on the paper Associate Professor Young."

Serotonin is increased in autism